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Beilstein J. Org. Chem. 2019, 15, 2524–2533, doi:10.3762/bjoc.15.245
Graphical Abstract
Figure 1: Some hydroxamic acid-based anti-tumor drugs.
Scheme 1: Synthesis of SAHA and DDSAHA.
Figure 2: Cell viability from MTT assay for SAHA, 11b, 11f and 11g on HeLa after 24 h treatment.
Figure 3: Percent of cell death by LDH assay at a GI50 dose of SAHA, 11b, 11f and 11g after 24 h incubation a...
Figure 4: ROS generation by DCFDA.
Figure 5: The quantitative results of bivariate FITC-Annexin V/PI FCM of HeLa cells after treatment with 11b ...
Figure 6: Fluorescence microscopic images of 11b at different concentrations (8.9, and 14.2 µM, respectively)...
Figure 7: DNA Ladder formation in a gel electrophoresis study of 11b at different concentrations (at 8.9, and...
Beilstein J. Org. Chem. 2014, 10, 3104–3110, doi:10.3762/bjoc.10.327
Figure 1: Selected polyhydroxyindolizidine and quinolizidines of importance.
Figure 2: Target bicyclic imino sugars Ia and Ib from a common intermediate IV.
Scheme 1: Reagents and conditions: (i) Zn/AcOH, rt, 1 h, 86%. (ii) TBSOTf, DIPEA, CH2Cl2, −5 °C, 1 h, 91%. (i...
Scheme 2: Reagents and conditions: (i) OsO4, NMO, acetone/water, rt, 12 h, 96%. (ii) NaH, THF, BnBr, Bu4NI, 0...
Figure 3: Selected nOe correlations (A) and coupling constants (B) for compound 15.
Figure 4: 1H,1H COSY spectrum of compound 15.
Scheme 3: Reagents and conditions: (i) OsO4, NMO, acetone/water, 6 h, 95%. (ii) NaH, THF, BnBr, Bu4NI, 0 °C t...
Figure 5: Selected nOe correlations and part NOESY spectrum of compound 23 in D2O (600 MHz).
Beilstein J. Org. Chem. 2013, 9, 2910–2915, doi:10.3762/bjoc.9.327
Figure 1: Balanol (1) and ophiocordin (2).
Figure 2: Strategic bond disconnections of balanol.
Scheme 1: Synthesis of the benzophenone fragment of balanol.
Scheme 2: Synthesis of the hexahydroazepine core of balanol.
Scheme 3: Synthesis of balanol and an analogue.